The 20th International Forum on Mood and Anxiety Disorders (IFMAD) annual congress will take place on 4 – 6 June 2025 in Budapest, Hungary. The forum will delve into exciting new developments in treatment–resistant mood and anxiety disorders, explore novel therapeutic approaches, and examine the impact of the gut microbiota on mental health. Discussions will also include the latest in dementia treatment, the evolving role of genetics and psychotherapy in psychiatric care, and how emerging therapies like psilocybin are reshaping our understanding of treatment efficacy. Speakers will further address the management of cognitive impairments in both schizophrenia and bipolar disorder, among other key topics.